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The Huynh Lab is located in Duncan Hall at San José State University. We study how nutrients are metabolized and how this contributes to overall health. The way nutrients are metabolized and stored can have profound effects on most physiological processes. The Huynh Lab uses a multidisciplinary approach to study how carbohydrate, lipid, and amino acid metabolic pathways are regulated, how they interact, and how dysregulation of these pathways can lead to diseases such as diabetes and obesity. We are particularly interested in how metabolic pathways are regulated by hormones and post-translational modifications.



For an updated list of publications, please visit: 

Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., Hirschey, M. D., Cohen, H. Y. (2019). SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell reports, 29(12), 4127–4143.e8.


Tudurí, E., Glavas, M. M., Asadi, A., Baker, R. K., Ellis, C. E., Soukhatcheva, G., Philit, M., Huynh, F. K., Johnson, J. D., Bruce Verchere, C., & Kieffer, T. J. (2019). AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells. Scientific reports, 9(1), 10829.

Ali, H. R., Assiri, M. A., Harris, P. S., Michel, C. R., Yun, Y., Marentette, J. O., Huynh, F. K., Orlicky, D. J., Shearn, C. T., Saba, L. M., Reisdorph, R., Reisdorph, N., Hirschey, M. D., & Fritz, K. S. (2019). Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism. Journal of proteome research, 18(4), 1513–1531.

Nicholatos, J. W., Robinette, T. M., Tata, S., Yordy, J. D., Francisco, A. B., Platov, M., Yeh, T. K., Ilkayeva, O. R., Huynh, F. K., Dokukin, M., Volkov, D., Weinstein, M. A., Boyko, A. R., Miller, R. A., Sokolov, I., Hirschey, M. D., & Libert, S. (2019). Cellular energetics and mitochondrial uncoupling in canine aging. GeroScience, 41(2), 229–242.


Huynh, F. K., Hu, X., Lin, Z., Johnson, J. D., & Hirschey, M. D. (2018). Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. Journal of inherited metabolic disease, 41(1), 59–72.


Anderson, K. A., Huynh, F. K., Fisher-Wellman, K., Stuart, J. D., Peterson, B. S., Douros, J. D., Wagner, G. R., Thompson, J. W., Madsen, A. S., Green, M. F., Sivley, R. M., Ilkayeva, O. R., Stevens, R. D., Backos, D. S., Capra, J. A., Olsen, C. A., Campbell, J. E., Muoio, D. M., Grimsrud, P. A., & Hirschey, M. D. (2017). SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell metabolism, 25(4), 838–855.e15.


Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D., & Mair, W. B. (2017). Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. Cell metabolism, 26(6), 884–896.e5.


Madsen, A. S., Andersen, C., Daoud, M., Anderson, K. A., Laursen, J. S., Chakladar, S., Huynh, F. K., Colaço, A. R., Backos, D. S., Fristrup, P., Hirschey, M. D., & Olsen, C. A. (2016). Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. The Journal of biological chemistry, 291(13), 7128–7141.


Burkewitz, K., Morantte, I., Weir, H., Yeo, R., Zhang, Y., Huynh, F. K., Ilkayeva, O. R., Hirschey, M. D., Grant, A. R., & Mair, W. B. (2015). Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell, 160(5), 842–855.


Huynh, F. K., Muoio, D. M., & Hirschey, M. D. (2015). SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control. Diabetes, 64(9), 3058–3060.


Anderson, K. A., Green, M. F., Huynh, F. K., Wagner, G. R., & Hirschey, M. D. (2014). SnapShot: Mammalian Sirtuins. Cell, 159(4), 956–956.e1.


Huynh, F. K., Green, M. F., Koves, T. R., & Hirschey, M. D. (2014). Measurement of fatty acid oxidation rates in animal tissues and cell lines. Methods in enzymology, 542, 391–405.


Huynh, F. K., Hershberger, K. A., & Hirschey, M. D. (2013). Targeting sirtuins for the treatment of diabetes. Diabetes management (London, England), 3(3), 245–257.


Huynh, F. K., Neumann, U. H., Wang, Y., Rodrigues, B., Kieffer, T. J., & Covey, S. D. (2013). A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice. Hepatology (Baltimore, Md.), 57(2), 543–554.


Denroche, H. C., Huynh, F. K., & Kieffer, T. J. (2012). The role of leptin in glucose homeostasis. Journal of diabetes investigation, 3(2), 115–129.


Levi, J., Huynh, F. K., Denroche, H. C., Neumann, U. H., Glavas, M. M., Covey, S. D., & Kieffer, T. J. (2012). Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice. Diabetologia, 55(3), 752–762.


Denroche, H. C., Levi, J., Wideman, R. D., Sequeira, R. M., Huynh, F. K., Covey, S. D., & Kieffer, T. J. (2011). Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes, 60(5), 1414–1423.


Levi, J., Gray, S. L., Speck, M., Huynh, F. K., Babich, S. L., Gibson, W. T., & Kieffer, T. J. (2011). Acute disruption of leptin signaling in vivo leads to increased insulin levels and insulin resistance. Endocrinology, 152(9), 3385–3395.


Huynh, F. K., Levi, J., Denroche, H. C., Gray, S. L., Voshol, P. J., Neumann, U. H., Speck, M., Chua, S. C., Covey, S. D., & Kieffer, T. J. (2010). Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes, 59(12), 3032–3040.


Covey, S. D., Wideman, R. D., McDonald, C., Unniappan, S., Huynh, F., Asadi, A., ... & Kieffer, T. J. (2006). The pancreatic β cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell metabolism, 4(4), 291-302.



Graduation Caps


Frank K. Huynh

Dr. Frank Huynh obtained a Bachelor of Science in Biochemistry and PhD in Physiology from the University of British Columbia. During his PhD, he studied the effects of the appetite-suppressing hormone leptin on regulating glucose and lipid metabolism. Dr. Huynh completed his post-doctoral training at Duke University Medical Center, where he studied the metabolic functions of a family of enzymes called sirtuins, which are deacylase enzymes and thought to have anti-aging properties. At San José State University, Dr. Huynh continues to investigate how nutrients are metabolized and how this contributes to both normal and pathological processes.


Dr. Huynh is also passionate about teaching. He has extensive experience teaching physiology labs. Dr. Huynh is constantly striving to find better ways to teach physiology through methods that encourage critical thinking and development of practical skills. His current courses are listed below:


Biol 125 - Systems Physiology Lab

Biol 178 - Integrative Physiology

Aeowynn J. Coakley

Biological Sciences - Systems Physiology

Minors: Chemistry; Nutrition & Food Science

F. ALbert and Dororthy Ellis Scholarship & Dean's Scholarship - College of Science

Arshia Hamzehpour S.

Biological Sciences - Systems Physiology

Minor: Chemistry

Undergraduate Research Grant 2019 - 2020

& Claudia Greathead Scholarship

Fiara Llaguno

Biomedical Engineering

Undergraduate Research Grant 2019 - 2020 & CSUPERB 2020 Poster Presenter

Albert Nguyen 

Biological Sciences - Molecular Biology

Minor: Chemistry

Undergraduate Research Grant 2019 - 2020 & CSUPERB 2020 Poster Presenter

Tina Nguyen 

Biological Sciences - Microbiology

Minor: Chemistry

Howell - CSUPERB Research Scholar

2019 - 2020

Michael Wan Hua Ouyang

Biological Sciences - Systems Physiology

Minor: Chemistry

CSUPERB Presidents' Commission Scholar 2018 - 2019 

Ana Lopez

Biological Sciences - Molecular Biology

Minor: Chemistry

Spartan M.D. Club Vice - President &

Peer Connections Mentor

Kenneth M. Lum

Biological Sciences - Molecular Biology

Minor: Chemistry

Undergraduate Research Grant 2019 - 2020

Fatin Mustafa

Biological Sciences - Systems Physiology

Minors: Chemistry; Business

Undergraduate Research Grant 2019 - 2020

Kristopher Strunk

Biological Sciences - Systems Physiology

Minor: Chemistry



Photo Album



Dr. Frank K. Huynh

Duncan Hall 336

Office: 1-408-924-4880

Lab: 1-408-924-4212


San Jose State University

Biology Department

ATTN: Dr. Frank Huynh

129 South 10th Street

San Jose, CA 95192-0100

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The Huynh Lab is currently accepting applications for graduate students and undergraduate students

If you are interested, contact Dr. Huynh via email with your CV, unofficial transcript, long-term career goals, and why you want to join the Huynh Lab.