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The Huynh Lab is located in Duncan Hall at San José State University. We study how nutrients are metabolized and how this contributes to overall health. The way nutrients are metabolized and stored can have profound effects on most physiological processes. The Huynh Lab uses a multidisciplinary approach to study how carbohydrate, lipid, and amino acid metabolic pathways are regulated, how they interact, and how dysregulation of these pathways can lead to diseases such as diabetes and obesity. We are particularly interested in how metabolic pathways are regulated by hormones and post-translational modifications.



For an updated list of publications, please visit: 

Huynh, F. K., Peterson, B. S., Anderson, K. A., Lin, Z., Coakley, A. J., Llaguno, F., Nguyen, T. N., Campbell, J. E., Stephens, S. B., Newgard, C. B., & Hirschey, M. D. (2020). β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice. American journal of physiology. Endocrinology and metabolism, 319(4), E805–E813.

Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., Hirschey, M. D., Cohen, H. Y. (2019). SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell reports, 29(12), 4127–4143.e8.


Tudurí, E., Glavas, M. M., Asadi, A., Baker, R. K., Ellis, C. E., Soukhatcheva, G., Philit, M., Huynh, F. K., Johnson, J. D., Bruce Verchere, C., & Kieffer, T. J. (2019). AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells. Scientific reports, 9(1), 10829.

Ali, H. R., Assiri, M. A., Harris, P. S., Michel, C. R., Yun, Y., Marentette, J. O., Huynh, F. K., Orlicky, D. J., Shearn, C. T., Saba, L. M., Reisdorph, R., Reisdorph, N., Hirschey, M. D., & Fritz, K. S. (2019). Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism. Journal of proteome research, 18(4), 1513–1531.

Nicholatos, J. W., Robinette, T. M., Tata, S., Yordy, J. D., Francisco, A. B., Platov, M., Yeh, T. K., Ilkayeva, O. R., Huynh, F. K., Dokukin, M., Volkov, D., Weinstein, M. A., Boyko, A. R., Miller, R. A., Sokolov, I., Hirschey, M. D., & Libert, S. (2019). Cellular energetics and mitochondrial uncoupling in canine aging. GeroScience, 41(2), 229–242.


Huynh, F. K., Hu, X., Lin, Z., Johnson, J. D., & Hirschey, M. D. (2018). Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. Journal of inherited metabolic disease, 41(1), 59–72.


Anderson, K. A., Huynh, F. K., Fisher-Wellman, K., Stuart, J. D., Peterson, B. S., Douros, J. D., Wagner, G. R., Thompson, J. W., Madsen, A. S., Green, M. F., Sivley, R. M., Ilkayeva, O. R., Stevens, R. D., Backos, D. S., Capra, J. A., Olsen, C. A., Campbell, J. E., Muoio, D. M., Grimsrud, P. A., & Hirschey, M. D. (2017). SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell metabolism, 25(4), 838–855.e15.


Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D., & Mair, W. B. (2017). Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. Cell metabolism, 26(6), 884–896.e5.


Madsen, A. S., Andersen, C., Daoud, M., Anderson, K. A., Laursen, J. S., Chakladar, S., Huynh, F. K., Colaço, A. R., Backos, D. S., Fristrup, P., Hirschey, M. D., & Olsen, C. A. (2016). Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. The Journal of biological chemistry, 291(13), 7128–7141.


Burkewitz, K., Morantte, I., Weir, H., Yeo, R., Zhang, Y., Huynh, F. K., Ilkayeva, O. R., Hirschey, M. D., Grant, A. R., & Mair, W. B. (2015). Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell, 160(5), 842–855.


Huynh, F. K., Muoio, D. M., & Hirschey, M. D. (2015). SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control. Diabetes, 64(9), 3058–3060.


Anderson, K. A., Green, M. F., Huynh, F. K., Wagner, G. R., & Hirschey, M. D. (2014). SnapShot: Mammalian Sirtuins. Cell, 159(4), 956–956.e1.


Huynh, F. K., Green, M. F., Koves, T. R., & Hirschey, M. D. (2014). Measurement of fatty acid oxidation rates in animal tissues and cell lines. Methods in enzymology, 542, 391–405.


Huynh, F. K., Hershberger, K. A., & Hirschey, M. D. (2013). Targeting sirtuins for the treatment of diabetes. Diabetes management (London, England), 3(3), 245–257.


Huynh, F. K., Neumann, U. H., Wang, Y., Rodrigues, B., Kieffer, T. J., & Covey, S. D. (2013). A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice. Hepatology (Baltimore, Md.), 57(2), 543–554.


Denroche, H. C., Huynh, F. K., & Kieffer, T. J. (2012). The role of leptin in glucose homeostasis. Journal of diabetes investigation, 3(2), 115–129.


Levi, J., Huynh, F. K., Denroche, H. C., Neumann, U. H., Glavas, M. M., Covey, S. D., & Kieffer, T. J. (2012). Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice. Diabetologia, 55(3), 752–762.


Denroche, H. C., Levi, J., Wideman, R. D., Sequeira, R. M., Huynh, F. K., Covey, S. D., & Kieffer, T. J. (2011). Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes, 60(5), 1414–1423.


Levi, J., Gray, S. L., Speck, M., Huynh, F. K., Babich, S. L., Gibson, W. T., & Kieffer, T. J. (2011). Acute disruption of leptin signaling in vivo leads to increased insulin levels and insulin resistance. Endocrinology, 152(9), 3385–3395.


Huynh, F. K., Levi, J., Denroche, H. C., Gray, S. L., Voshol, P. J., Neumann, U. H., Speck, M., Chua, S. C., Covey, S. D., & Kieffer, T. J. (2010). Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes, 59(12), 3032–3040.


Covey, S. D., Wideman, R. D., McDonald, C., Unniappan, S., Huynh, F., Asadi, A., ... & Kieffer, T. J. (2006). The pancreatic β cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell metabolism, 4(4), 291-302.



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Emily Nguyen 

Biomedical Engineering

Logistics Volunteer for the 2021 Bay Area Biomedical Device Conference with Biomedical Engineering Society (BMES)

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Michael Wan Hua Ouyang

Biological Sciences - Systems Physiology

Minor: Chemistry

CSUPERB Presidents' Commission Scholar 2018 - 2019 

Graduation Caps



Frank K. Huynh

Dr. Frank Huynh obtained a Bachelor of Science in Biochemistry and PhD in Physiology from the University of British Columbia. During his PhD, he studied the effects of the appetite-suppressing hormone leptin on regulating glucose and lipid metabolism. Dr. Huynh completed his post-doctoral training at Duke University Medical Center, where he studied the metabolic functions of a family of enzymes called sirtuins, which are deacylase enzymes and thought to have anti-aging properties. At San José State University, Dr. Huynh continues to investigate how nutrients are metabolized and how this contributes to both normal and pathological processes.


Dr. Huynh is also passionate about teaching. He has extensive experience teaching physiology labs. Dr. Huynh is constantly striving to find better ways to teach physiology through methods that encourage critical thinking and development of practical skills. His current courses are listed below:

Biol 125 - Systems Physiology Lab

Biol 131 - Endocrine Physiology

Biol 178 - Integrative Physiology

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Arshia Hamzehpour S.

Biological Sciences - Systems Physiology

Minor: Chemistry

Undergraduate Research Grant 2019 - 2020

Claudia Greathead Scholarship


Albert Nguyen

Biological Sciences - Molecular Biology

Minor: Chemistry

Undergraduate Research Grant 2019 - 2020 

CSUPERB 2020 Poster Presenter


Diane Dan Anh Nguyen

Biological Sciences - Systems Physiology

Minor: Chemistry

AA - Liberal Arts with Science, Math, & Engineering Emphasis

President's Scholar Spring 2020 

President's Scholar Fall 2020


Maggie Penney

Graduate Student

B.S. Biological Sciences - Systems Physiology

San Jose State University, 2020

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Joanne Khau

Graduate Student

B.S. Biological Sciences - Systems Physiology

San Jose State University, 2019



Photo Album



Dr. Frank K. Huynh

Duncan Hall 336

Office: 1-408-924-4880

Lab: 1-408-924-4212


San Jose State University

Biology Department

ATTN: Dr. Frank Huynh

129 South 10th Street

San Jose, CA 95192-0100

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The Huynh Lab is currently accepting applications for graduate students and undergraduate students

If you are interested, contact Dr. Huynh via email with your CV, unofficial transcript, expected graduation date, long-term career goals, and why you want to join the Huynh Lab.

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